Histopathologic features of ovarian borderline tumors are not predictive of clinical outcome.

@article{Avril2012HistopathologicFO,
  title={Histopathologic features of ovarian borderline tumors are not predictive of clinical outcome.},
  author={Stefanie Avril and Ellen Hahn and Katja Specht and Steffen Hauptmann and Cornelia Hoess and Marion Kiechle and Heinz Hoefler and Barbara Schmalfeldt},
  journal={Gynecologic oncology},
  year={2012},
  volume={127 3},
  pages={516-24}
}
OBJECTIVES Ovarian borderline tumors (BOTs) generally have an excellent prognosis, although recurrences and malignant transformation can occur. Our aim was to compare clinicopathologic features of BOT with clinical outcome. METHODS In seventy consecutive BOTs clinicopathologic parameters, tumor cell proliferation (Ki67) and in selected cases KRAS, BRAF and p53 mutational status were analyzed with recurrence-free and overall survival as the endpoints. RESULTS Sixty-one (87%) patients… CONTINUE READING