Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis

@inproceedings{Stephenson2011HistopathologicCO,
  title={Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis},
  author={Diane Stephenson and Sharon M O'Neill and Sapna Narayan and Aadhya Tiwari and Elizabeth Arnold and Harry D Samaroo and Fu Du and Robert H Ring and Brian M Campbell and Mathew T. Pletcher and Vidita A. Vaidya and Daniel Morton},
  booktitle={Molecular autism},
  year={2011}
}
BACKGROUND The inbred mouse strain BTBR T+ tf/J (BTBR) exhibits behavioral deficits that mimic the core deficits of autism. Neuroanatomically, the BTBR strain is also characterized by a complete absence of the corpus callosum. The goal of this study was to identify novel molecular and cellular changes in the BTBR mouse, focusing on neuronal, synaptic, glial and plasticity markers in the limbic system as a model for identifying putative molecular and cellular substrates associated with autistic… CONTINUE READING