Histopathologic changes in the testes of rats exposed to dibromoacetic acid.

  title={Histopathologic changes in the testes of rats exposed to dibromoacetic acid.},
  author={R E Linder and Gary Robert Klinefelter and Lillian F. Strader and D. N. Rao Veeramachaneni and Naomi L Roberts and Juan D. Suarez},
  journal={Reproductive toxicology},
  volume={11 1},
The present report details histopathologic changes in the testis and epididymis of rats gavaged daily for 2 to 79 d with a by-product of water disinfection, dibromoacetic acid (DBAA). On treatment day 2 abnormal retention of Step 19 spermatids was observed in animals given the highest dosage of 250 mg/kg. Additional changes on day 5 included the fusion of mature spermatids and the presence of atypical residual bodies (ARB) in the epithelium and lumen of Stage X-XII seminiferous tubules. By day… CONTINUE READING


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