Histopathologic and immunologic effects of the itraconazole treatment in a murine model of chronic pulmonary paracoccidioidomycosis.

@article{Naranjo2010HistopathologicAI,
  title={Histopathologic and immunologic effects of the itraconazole treatment in a murine model of chronic pulmonary paracoccidioidomycosis.},
  author={Tonny Williams Naranjo and Damaris Elena Lopera and Lucy R Diaz-Granados and Jhon J Duque and Angela Maria Restrepo and Luz Elena Cano},
  journal={Microbes and infection},
  year={2010},
  volume={12 14-15},
  pages={1153-62}
}
A comparative study, based on histopathologic findings (inflammation, cellularity, and fibrosis) and immunologic parameters (pro-inflammatory and anti-inflammatory cytokines), was carried out in order to evaluate the effects of itraconazole (ITC) treatment and its starting time in a BALB/c murine model of chronic pulmonary paracoccidioidomycosis (PCM), induced by intranasal inoculation of Paracoccidioides brasiliensis (Pb) conidia. Two different groups of mice were exposed to ITC therapy… CONTINUE READING
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