Histopathologic Features of Colitis Due to Immunotherapy With Anti-PD-1 Antibodies.

@article{Chen2017HistopathologicFO,
  title={Histopathologic Features of Colitis Due to Immunotherapy With Anti-PD-1 Antibodies.},
  author={Jonathan H. Chen and Maryam Kherad Pezhouh and Gregory Yves Lauwers and Ricard Masia},
  journal={The American journal of surgical pathology},
  year={2017},
  volume={41 5},
  pages={643-654}
}
Programmed cell death protein 1 (PD-1) blocking agents are novel immunotherapeutics used for treatment of advanced-stage malignancies. They have shown promise in the treatment of several malignancies, with greater efficacy and better tolerability than cytotoxic T-lymphocyte antigen 4 (CTLA-4) blocking agents. However, as with anti-CTLA-4 agents, clinically significant colitis remains an important complication. Although there is growing awareness of the histopathologic features of anti-CTLA-4… CONTINUE READING
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