Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury.

@article{Huang2013HistonesAT,
  title={Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury.},
  author={Hai Huang and Hui-Wei Chen and John Evankovich and Wei Yan and Brian R. Rosborough and Gary W. Nace and Qing Ding and Patricia Loughran and Donna Beer-Stolz and Timothy R Billiar and Charles T. Esmon and Allan Tsung},
  journal={Journal of immunology},
  year={2013},
  volume={191 5},
  pages={2665-79}
}
Cellular processes that drive sterile inflammatory injury after hepatic ischemia/reperfusion (I/R) injury are not completely understood. Activation of the inflammasome plays a key role in response to invading intracellular pathogens, but mounting evidence suggests that it also plays a role in inflammation driven by endogenous danger-associate molecular pattern molecules released after ischemic injury. The nucleotide-binding domain, leucine-rich repeat containing protein 3 (NLRP3) inflammasome… CONTINUE READING
48 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

Similar Papers

Loading similar papers…