Histone trimethylation of the p53 gene by expression of a constitutively active prolactin receptor in prostate cancer cells.

@article{Tan2013HistoneTO,
  title={Histone trimethylation of the p53 gene by expression of a constitutively active prolactin receptor in prostate cancer cells.},
  author={Dunyong Tan and Si Tan and Jie Zhang and Peizhi Tang and Jianjun Huang and W Zhou and Shijun Wu},
  journal={The Chinese journal of physiology},
  year={2013},
  volume={56 5},
  pages={282-90}
}
Prolactin (PRL) is a pituitary polypeptide hormone characterized by multiple biological actions including stimulation of growth in the prostate, breast and ovarian epithelial cells. A sizable body of reports has presented evidences to indicate the involvement of PRL in the pathogenic process of cancers of the reproductive system, such as prostate and breast cancers. PRL exerts its effects by dimerizing its receptor (PRLR) on the plasma membrane, and initiating cellular Jak-Stat signal pathway… CONTINUE READING