Histone-targeted Polyplexes Avoid Endosomal Escape and Enter the Nucleus During Postmitotic Redistribution of ER Membranes

@inproceedings{Ross2015HistonetargetedPA,
  title={Histone-targeted Polyplexes Avoid Endosomal Escape and Enter the Nucleus During Postmitotic Redistribution of ER Membranes},
  author={Nikki L Ross and Erik V Munsell and Chandran R Sabanayagam and Millicent O. Sullivan},
  booktitle={Molecular therapy. Nucleic acids},
  year={2015}
}
Nonviral gene delivery is a promising therapeutic approach because of its safety and controllability, yet limited gene transfer efficacy is a common issue. Most nonviral strategies rely upon endosomal escape designs; however, endosomal escape is often uncorrelated with improved gene transfer and membranolytic structures are typically cytotoxic. Previously, we showed that histone-targeted polyplexes trafficked to the nucleus through an alternative route involving caveolae and the Golgi and… CONTINUE READING