Histone modifying enzymes: novel disease biomarkers and assay development.

@article{Ma2016HistoneME,
  title={Histone modifying enzymes: novel disease biomarkers and assay development.},
  author={Fei Chun Ma and Chun-Yang Zhang},
  journal={Expert review of molecular diagnostics},
  year={2016},
  volume={16 3},
  pages={297-306}
}
Histones are the chief components of chromatin. When being catalyzed by a series of histone modifying enzymes, histones may undergo various post-translational modifications such as acetylation, methylation, phosphorylation, ubiquitylation and SUMOylation. The dysregulation of histone modifying enzymes will alter the histone post-modification patterns and cause diverse diseases including cancers. Consequently, the histone modifying enzymes have emerged as the promising biomarkers for disease… CONTINUE READING
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