Histone-modifying complexes regulate gene expression pertinent to the differentiation of the protozoan parasite Toxoplasma gondii.

@article{Saksouk2005HistonemodifyingCR,
  title={Histone-modifying complexes regulate gene expression pertinent to the differentiation of the protozoan parasite Toxoplasma gondii.},
  author={Nehm{\'e} Saksouk and Micah M. Bhatti and Sylvie Kieffer and Aaron T. Smith and Karine Musset and J{\'e}r{\^o}me Garin and William J Sullivan and Marie-France Cesbron-Delauw and Mohamed-Ali Hakimi},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 23},
  pages={10301-14}
}
Pathogenic apicomplexan parasites like Toxoplasma and Plasmodium (malaria) have complex life cycles consisting of multiple stages. The ability to differentiate from one stage to another requires dramatic transcriptional changes, yet there is a paucity of transcription factors in these protozoa. In contrast, we show here that Toxoplasma possesses extensive chromatin remodeling machinery that modulates gene expression relevant to differentiation. We find that, as in other eukaryotes, histone… CONTINUE READING

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