Histone modifications induced by a family of bacterial toxins.

  title={Histone modifications induced by a family of bacterial toxins.},
  author={M{\'e}lanie Anne Hamon and Eric Batsch{\'e} and B{\'e}atrice Regnault and To Nam Tham and Stephanie M. Seveau and Christian Muchardt and Pascale Cossart},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 33},
Upon infection, pathogens reprogram host gene expression. In eukaryotic cells, genetic reprogramming is induced by the concerted activation/repression of transcription factors and various histone modifications that control DNA accessibility in chromatin. We report here that the bacterial pathogen Listeria monocytogenes induces a dramatic dephosphorylation of histone H3 as well as a deacetylation of histone H4 during early phases of infection. This effect is mediated by the major listerial toxin… CONTINUE READING
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