Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome.

@article{Coffee2002HistoneMD,
  title={Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome.},
  author={Bradford W. Coffee and Fuping Zhang and Stephanie S. Ceman and Stephen T Warren and Daniel Reines},
  journal={American journal of human genetics},
  year={2002},
  volume={71 4},
  pages={923-32}
}
Fragile X syndrome is caused by an expansion of a polymorphic CGG triplet repeat that results in silencing of FMR1 expression. This expansion triggers methylation of FMR1's CpG island, hypoacetylation of associated histones, and chromatin condensation, all characteristics of a transcriptionally inactive gene. Here, we show that there is a graded spectrum of histone H4 acetylation that is proportional to CGG repeat length and that correlates with responsiveness of the gene to DNA demethylation… CONTINUE READING