Histone modifications are associated with Δ9-tetrahydrocannabinol-mediated alterations in antigen-specific T cell responses.

@article{Yang2014HistoneMA,
  title={Histone modifications are associated with Δ9-tetrahydrocannabinol-mediated alterations in antigen-specific T cell responses.},
  author={Xiaoming Yang and Venkatesh L. Hegde and Roshni Rao and Jiajia Zhang and Prakash Nagarkatti and Mitzi Nagarkatti},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 27},
  pages={18707-18}
}
Marijuana is one of the most abused drugs due to its psychotropic effects. Interestingly, it is also used for medicinal purposes. The main psychotropic component in marijuana, Δ(9)-tetrahydrocannabinol (THC), has also been shown to mediate potent anti-inflammatory properties. Whether the immunomodulatory activity of THC is mediated by epigenetic regulation has not been investigated previously. In this study, we employed ChIP-Seq technology to examine the in vivo effect of THC on global histone… CONTINUE READING
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