Histone modifications: signalling receptors and potential elements of a heritable epigenetic code.

@article{Nightingale2006HistoneMS,
  title={Histone modifications: signalling receptors and potential elements of a heritable epigenetic code.},
  author={Karl P. Nightingale and L P O'neill and Bryan M. Turner},
  journal={Current opinion in genetics & development},
  year={2006},
  volume={16 2},
  pages={125-36}
}
The genetic code epitomises simplicity, near universality and absolute predictive power. By contrast, epigenetic information, in the form of histone modifications, is characterised by complexity, diversity and an overall tendency to respond to changes in genomic function rather than to predict them. Perhaps the transient changes in histone modifications involved in intranuclear signalling and ongoing chromatin functions mask stable, predictive modifications that lie beneath. The current rapid… CONTINUE READING
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