Histone modifications, DNA methylation, and schizophrenia.

  title={Histone modifications, DNA methylation, and schizophrenia.},
  author={David Gavin and Rajiv P. Sharma},
  journal={Neuroscience and biobehavioral reviews},
  volume={34 6},
Studies have demonstrated that several schizophrenia candidate genes are especially susceptible to changes in transcriptional activity as a result of histone modifications and DNA methylation. Increased expression of epigenetic enzymes which generally reduce transcription have been reported in schizophrenia postmortem brain samples. An abnormal chromatin… CONTINUE READING