Histone modification and replacement in chromatin activation.

@article{Goll2002HistoneMA,
  title={Histone modification and replacement in chromatin activation.},
  author={Mary Grace Goll and Timothy H Bestor},
  journal={Genes & development},
  year={2002},
  volume={16 14},
  pages={
          1739-42
        }
}
Histones are subject to a complex and dynamic set of covalent modifications that are thought to be involved in the modulation of transcription during development, in X chromosome inactivation in female mammals, and in genome stability and meiotic chromosome dynamics. Histone modifications reported to date include acetylation, phosphorylation, methylation, ADP ribosylation, and ubiquitination (Fig. 1). Multiple residues on each of the four core histones have been identified as potential… CONTINUE READING

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