Histone methylation-mediated silencing of miR-139 enhances invasion of non-small-cell lung cancer

@inproceedings{Watanabe2015HistoneMS,
  title={Histone methylation-mediated silencing of miR-139 enhances invasion of non-small-cell lung cancer},
  author={Kousuke Watanabe and Yosuke Amano and Rie Ishikawa and Mitsuhiro Sunohara and Hidenori Kage and Junji Ichinose and Atsushi Sano and Jun -Ichiro Nakajima and Masashi Fukayama and Yutaka Yatomi and Takahide Nagase and Nobuya Ohishi and Daiya Takai},
  booktitle={Cancer medicine},
  year={2015}
}
MicroRNA expression is frequently altered in human cancers, and some microRNAs act as oncogenes or tumor suppressors. MiR-139-5p (denoted thereafter as miR-139) has recently been reported to function as a tumor suppressor in several types of human cancer (hepatocellular carcinoma, colorectal cancer, breast cancer, and gastric cancer), but its function in non-small-cell lung cancer (NSCLC) and the mechanism of its suppression have not been studied in detail. MiR-139 was suppressed frequently in… CONTINUE READING
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