Histone methylation marks play important roles in predicting the methylation status of CpG islands.

@article{Fan2008HistoneMM,
  title={Histone methylation marks play important roles in predicting the methylation status of CpG islands.},
  author={Shicai Fan and Michael Q Zhang and Xuegong Zhang},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={374 3},
  pages={559-64}
}
The methylation status of CpG islands is highly correlated with gene expression. Current methods for computational prediction of DNA methylation only utilize DNA sequence features. In this study, besides 35 DNA sequence features, we added four histone methylation marks to predict the methylation status of CpG islands, and improved the accuracy to 89.94%. Also we applied our model to predict the methylation pattern of all the CpG islands in the human genome, and the results are consistent with… CONTINUE READING

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  • M. Weber, I. Hellmann, +4 authors D. Schubeler
  • silencing potential and evolutionary impact of…
  • 2007
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