Histone methylation defines epigenetic asymmetry in the mouse zygote.

  title={Histone methylation defines epigenetic asymmetry in the mouse zygote.},
  author={Katharine L. Arney and Siqin Bao and Andrew J. Bannister and Tony Kouzarides and M. Azim Surani},
  journal={The International journal of developmental biology},
  volume={46 3},
The oocyte cytoplasm regulates and enhances the epigenetic asymmetry between parental genomes and, consequently, functional differences observed between them during development in mammals. Here we demonstrate a preferential interaction of HP1beta with the maternal genome immediately after fertilisation in the mouse zygote, which also shows a high level of lysine 9-methylated histone H3. In contrast, the paternal genome has neither HP1beta binding nor methylated histone H3 at these early stages… CONTINUE READING


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