Histone marks: repairing DNA breaks within the context of chromatin.

@article{Miller2012HistoneMR,
  title={Histone marks: repairing DNA breaks within the context of chromatin.},
  author={Kyle M Miller and Stephen P. Jackson},
  journal={Biochemical Society transactions},
  year={2012},
  volume={40 2},
  pages={
          370-6
        }
}
Inherited or acquired defects in detecting, signalling or repairing DNA damage are associated with various human pathologies, including immunodeficiencies, neurodegenerative diseases and various forms of cancer. Nuclear DNA is packaged into chromatin and therefore the true in vivo substrate of damaged DNA occurs within the context of chromatin. Our work aims to decipher the mechanisms by which cells detect DNA damage and signal its presence to the DNA-repair and cell-cycle machineries. In… CONTINUE READING
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