Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay.

@article{Cheung2015HistoneMI,
  title={Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay.},
  author={Jennifer R Cheung and Donna A Dickinson and Jocelyn Moss and Maik J Schuler and Richard A Spellman and Pamela L Heard},
  journal={Mutation research. Genetic toxicology and environmental mutagenesis},
  year={2015},
  volume={777},
  pages={7-16}
}
The in vitro micronucleus assay with TK6 cells is frequently used as part of the genotoxicity testing battery for pharmaceuticals. Consequently, follow-up testing strategies are needed for positive compounds to determine their mode of action, which would then allow for deployment of appropriate in vivo follow-up strategies. We have chosen 3 micronucleus positive compounds, the clastogen etoposide, the aneugen noscapine and the cytotoxicant tunicamycin to evaluate different approaches to… CONTINUE READING