Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay.

Abstract

The in vitro micronucleus assay with TK6 cells is frequently used as part of the genotoxicity testing battery for pharmaceuticals. Consequently, follow-up testing strategies are needed for positive compounds to determine their mode of action, which would then allow for deployment of appropriate in vivo follow-up strategies. We have chosen 3 micronucleus… (More)
DOI: 10.1016/j.mrgentox.2014.11.002

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