Histone lysine methylation patterns in human cell types are arranged in distinct three-dimensional nuclear zones

Abstract

The impact of histone lysine methylation as an essential epigenetic mechanism for gene regulation has been demonstrated by numerous studies where it was functionally and structurally linked to euchromatin and heterochromatin. Most of these data have been obtained by biochemical and two-dimensional (2D)-microscopic techniques providing little information… (More)
DOI: 10.1007/s00418-005-0049-1

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