• Corpus ID: 53356727

Histone lysine demethylases as epigenetic modifiers in HPV-induced cervical neoplasia

  title={Histone lysine demethylases as epigenetic modifiers in HPV-induced cervical neoplasia},
  author={Iulian Iancu and Anca Botezatu and Adriana Plesa and Irina Huică and Demetra Gabriela Socolov and Gabriela Anton and Stefan S. Nicolau and Grigore T. Popa},
Epidemiologic data confirmed high-risk human papillomaviruses as etiological agents of cervical cancer. On the other hand genetic and epigenetic modifications are known to play an important role in carcinogenesis. Histone lysine-specific demethylases (KDMs) have been shown to contribute to development and progression of many types of cancer. We evaluated the possible role of KDMs in cervix oncogenesis by analysing their expression in patients with HPV-induced cervical lesions and cancer (86… 

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