Histone-like protein H1 (H-NS), DNA supercoiling, and gene expression in bacteria

@article{Hulton1990HistonelikePH,
  title={Histone-like protein H1 (H-NS), DNA supercoiling, and gene expression in bacteria},
  author={Christopher S.J. Hulton and Alexander Seirafi and Jay C. D. Hinton and Julie M. Sidebotham and Lesley Waddell and Graham D. Pavitt and Tom Owen-Hughes and Annick Spassky and Henri Buc and Christopher F. Higgins},
  journal={Cell},
  year={1990},
  volume={63},
  pages={631-642}
}

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TLDR
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TLDR
Findings in H1 have far‐reaching implications for the mechanisms by which gene expression is regulated and also, perhaps, for the control of bacterial virulence.

DNA supercoiling, chromatin structure and the regulation of gene expression

TLDR
Preliminary data suggest that altered binding of this protein to DNA in response to environmental stresses plays a role in the regulation of DNA supercoiling and gene expression.

Expression and mutational analysis of the nucleoid‐associated protein H‐NS of Salmonella typhimurium

The H‐NS (H1) protein is a major component of bacterial chromatin. Mutations in the hns (osmZ) gene encoding H‐NS are highly pleiotropic, affecting the expression of many unrelated genes in an

H-NS forms a superhelical protein scaffold for DNA condensation

TLDR
The observed superhelical structure establishes a mechanism for the self-association of H-NS via both an N-terminal antiparallel coiled-coil and a second, hitherto unidentified, helix-turn-helix dimerization interface at the C- terminal end of the oligomerization domain.

Eukaryotic-like histones in Chlamydia.

  • R. KaulW. Wenman
  • Biology
    Frontiers in bioscience : a journal and virtual library
  • 1998
TLDR
Recent advances on the eukaryotic-like histones that have set the stage for elucidation of the chlamydial developmental cycle are reviewed.
...

References

SHOWING 1-10 OF 58 REFERENCES

Protein H1: a role for chromatin structure in the regulation of bacterial gene expression and virulence?

TLDR
Findings in H1 have far‐reaching implications for the mechanisms by which gene expression is regulated and also, perhaps, for the control of bacterial virulence.

Proteins from the Prokaryotic Nucleoid. Structural and Functional Characterization of the Escherichia coli DNA-Binding Proteins NS (HU) and H-NS

TLDR
It is possible that the differences existing between the pro- and eukaryotic systems may merely reflect differences in the tactics that each system must have perfected in order to harmonize its DNA-packaging mechanism with its specific physiological requirements.

H1a, an E. coli DNA-binding protein which accumulates in stationary phase, strongly compacts DNA in vitro

TLDR
Acrylamide gel electrophoresis and sedimentation in sucrose gradient have shown that the protein H1a induces significant compaction into DNA, equivalent to that observed in nucleosome core although it introduces only a slight change in linking number.

Osmotic regulation of porin expression: a role for DNA supercoiling

TLDR
It is suggested that environmentally induced changes in DNA supercoiling may play a role in determining the level of porin expression, and these findings have implications for current models of Porin regulation.

Sequence determinants for H1 binding on Escherichia coli lac and gal promoters.

TLDR
Changes in accessibility of the minor groove surrounding the respective binding sites were observed for both H1-DNA and CRP-DNA complexes, and binding of H1 to the strong lac promoter mutants Ps and UV5 appears to change the conformational state of this DNA.

DNA supercoiling and the anaerobic and growth phase regulation of tonB gene expression

TLDR
The physiological regulation of tonB expression in response to anaerobiosis and growth phase appears to be mediated by environmentally induced changes in DNA superhelicity.

Histonelike proteins of bacteria.

TLDR
This work considers the protein called IHF to be histonelike because it can wrap DNA and because it has considerable amino acid sequence homology with HU, a small, basic, abundant, DNA-binding protein capable of wrapping DNA.
...