Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

@inproceedings{Wang2009HistoneHM,
  title={Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation},
  author={Yanming Wang and Ming Li and Sonja Stadler and Sarah K. Correll and Pingxin Li and Danchen Wang and Ryo Hayama and Lauriebeth Leonelli and Hyunsil Han and Sergei A Grigoryev and C David Allis and Scott A Coonrod},
  booktitle={The Journal of cell biology},
  year={2009}
}
Peripheral blood neutrophils form highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs), that have been implicated in innate immune response to bacterial infection. Neutrophils express high levels of peptidylarginine deiminase 4 (PAD4), which catalyzes histone citrullination. However, whether PAD4 or histone citrullination plays a role in chromatin structure in neutrophils is unclear. In this study, we show that the hypercitrullination of histones by PAD4… CONTINUE READING
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