Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression.

Abstract

Active gene promoters are associated with covalent histone modifications, such as hyperacetylation, which can modulate chromatin structure and stabilize binding of transcription factors that recognize these modifications. At the beta-globin locus and several other loci, however, histone hyperacetylation extends beyond the promoter, over tens of kilobases… (More)
DOI: 10.1182/blood-2009-03-210690

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