Histone hyperacetylation facilitates chromatin remodelling in a Drosophila embryo cell-free system

@article{Krajewski2000HistoneHF,
  title={Histone hyperacetylation facilitates chromatin remodelling in a Drosophila embryo cell-free system},
  author={Wladyslaw A Krajewski},
  journal={Molecular and General Genetics MGG},
  year={2000},
  volume={263},
  pages={38-47}
}
Abstract We found that Drosophila embryo extract contains a protein activity (or activities) that can destabilize nucleosomes, resulting in increased sensitivity to DNase I, release of nucleosomal supercoiling, high levels of conformational flexibility of DNA and more diffuse micrococcal nuclease digestion patterns. Incorporation of histone H1 did not significantly affect this nucleosome remodelling. Remodelling occurs more efficiently in hyperacetylated chromatin. It was shown previously that… CONTINUE READING

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