Histone fold modifications control nucleosome unwrapping and disassembly.

@article{imon2011HistoneFM,
  title={Histone fold modifications control nucleosome unwrapping and disassembly.},
  author={Marek {\vS}imon and Justin North and John C. Shimko and Robert A. Forties and Michelle B. Ferdinand and Mridula Manohar and Meng Zhang and Richard Fishel and Jennifer J. Ottesen and Michael G Poirier},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 31},
  pages={
          12711-6
        }
}
Nucleosomes are stable DNA-histone protein complexes that must be unwrapped and disassembled for genome expression, replication, and repair. Histone posttranslational modifications (PTMs) are major regulatory factors of these nucleosome structural changes, but the molecular mechanisms associated with PTM function remains poorly understood. Here we demonstrate that histone PTMs within distinct structured regions of the nucleosome directly regulate the inherent dynamic properties of the… CONTINUE READING

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