Histone demethylases in development and disease.

  title={Histone demethylases in development and disease.},
  author={Marianne Terndrup Pedersen and Kristian Helin},
  journal={Trends in cell biology},
  volume={20 11},
Histone modifications serve as regulatory marks that are instrumental for the control of transcription and chromatin architecture. Strict regulation of gene expression patterns is crucial during development and differentiation, where diverse cell types evolve from common predecessors. Since the first histone lysine demethylase was discovered in 2004, a number of demethylases have been identified and implicated in the control of gene expression programmes and cell fate decisions. Histone… CONTINUE READING

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