Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

@inproceedings{Kerenyi2013HistoneDL,
  title={Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation},
  author={Marc A. Kerenyi and Zhen Shao and Yu-Jung Hsu and Guoji Guo and Sidinh Luc and Kassandra O'Brien and Yuko Fujiwara and C. Ray Peng and Minh Phuoc Nguyen and Stuart H Orkin},
  booktitle={eLife},
  year={2013}
}
Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis, combining global occupancy of Lsd1, genome-wide analysis of its substrates H3K4 monomethylation and dimethylation, and gene expression profiling, reveals that Lsd1 represses hematopoietic stem and progenitor cell (HSPC) gene expression programs during hematopoietic… CONTINUE READING