Histone demethylase LSD1 regulates neural stem cell proliferation.

  title={Histone demethylase LSD1 regulates neural stem cell proliferation.},
  author={Guoqiang Sun and Kamil J. Alzayady and Richard Stewart and Peng Ye and Su Cheol Yang and Wendong Li and Yan-hong Shi},
  journal={Molecular and cellular biology},
  volume={30 8},
Lysine-specific demethylase 1 (LSD1) functions as a transcriptional coregulator by modulating histone methylation. Its role in neural stem cells has not been studied. We show here for the first time that LSD1 serves as a key regulator of neural stem cell proliferation. Inhibition of LSD1 activity or knockdown of LSD1 expression led to dramatically reduced neural stem cell proliferation. LSD1 is recruited by nuclear receptor TLX, an essential neural stem cell regulator, to the promoters of TLX… CONTINUE READING


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