Histone demethylase KDM6B promotes epithelial-mesenchymal transition.

@article{Ramadoss2012HistoneDK,
  title={Histone demethylase KDM6B promotes epithelial-mesenchymal transition.},
  author={Sivakumar Ramadoss and Xiaohong Chen and Cun-yu Wang},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 53},
  pages={
          44508-17
        }
}
Epithelial-mesenchymal transition (EMT) is a critical event that occurs in embryonic development, tissue repair control, organ fibrosis, and carcinoma invasion and metastasis. Although significant progress has been made in understanding the molecular regulation of EMT, little is known about how chromatin is modified in EMT. Chromatin modifications through histone acetylation and methylation determine the precise control of gene expression. Recently, histone demethylases were found to play… CONTINUE READING
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