Histone demethylase KDM5A regulates the ZMYND8–NuRD chromatin remodeler to promote DNA repair

@inproceedings{Gong2017HistoneDK,
  title={Histone demethylase KDM5A regulates the ZMYND8–NuRD chromatin remodeler to promote DNA repair},
  author={Fade Gong and Thomas Clouaire and Marion Aguirrebengoa and Ga{\"e}lle Legube and Kyle M Miller},
  booktitle={The Journal of cell biology},
  year={2017}
}
Upon DNA damage, histone modifications are dynamically reshaped to accommodate DNA damage signaling and repair within chromatin. In this study, we report the identification of the histone demethylase KDM5A as a key regulator of the bromodomain protein ZMYND8 and NuRD (nucleosome remodeling and histone deacetylation) complex in the DNA damage response. We observe KDM5A-dependent H3K4me3 demethylation within chromatin near DNA double-strand break (DSB) sites. Mechanistically, demethylation of… CONTINUE READING
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