Histone decacetylase inhibitors prevent mitochondrial fragmentation and elicit early neuroprotection against MPP+.

@article{Zhu2014HistoneDI,
  title={Histone decacetylase inhibitors prevent mitochondrial fragmentation and elicit early neuroprotection against MPP+.},
  author={Min Zhu and Wen-Wei Li and Chuan-zhen Lu},
  journal={CNS neuroscience & therapeutics},
  year={2014},
  volume={20 4},
  pages={308-16}
}
BACKGROUND Parkinson's disease (PD) is a common neurodegenerative disease, characterized by progressive loss of dopaminergic (DA) neurons in the substantia nigra. Recent investigations have shown that mitochondrial fragmentation, an early event during apoptosis, is implicated in the degeneration of DA neurons in PD, and more importantly, preventing mitochondrial fragmentation could rescue cell death in several PD models. Therefore, mitochondrial dynamics may be a therapeutic target for early… CONTINUE READING

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