Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling

@article{Deroanne2002HistoneDI,
  title={Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling},
  author={Christophe F. Deroanne and Karine Bonjean and Sandrine Servotte and Laetitia Devy and Alain C. Colige and Nathalie Clausse and Sylvia Blacher and Eric Verdin and J. -M. Foidart and Betty V. Nusgens and Vincent Castronovo},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={427-436}
}
Angiogenesis is a complex biological process involving the coordinated modulation of many genes. Histone deacetylases (HDAC) are a growing family of enzymes that mediate the availability of chromatin to the transcriptional machinery. Trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA), two HDAC inhibitors known to relieve gene silencing, were evaluated as potential antiangiogenic agents. TSA and SAHA were shown to prevent vascular endothelial growth factor (VEGF)-stimulated human… CONTINUE READING

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