Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells.

@article{Buurman2012HistoneDA,
  title={Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells.},
  author={Reena Buurman and Engin Guerlevik and Vera Sch{\"a}ffer and Marlies Eilers and Maria Sandbothe and Hans Kreipe and L. Wilkens and Brigitte Schlegelberger and Florian K{\"u}hnel and Britta Skawran},
  journal={Gastroenterology},
  year={2012},
  volume={143 3},
  pages={811-820.e15}
}
BACKGROUND & AIMS Histone deacetylation regulates chromatin remodeling and transcriptional down-regulation of specific genomic regions; it is altered in many types of cancer cells. We searched for microRNAs (miRs) that are affected by histone deacetylation and investigated the effects in hepatocellular carcinoma (HCC) cells. METHODS HCC cell lines (HepG2, HLE, HLF, and Huh7) and immortalized liver cell lines (THLE-2 and THLE-3) were incubated with the histone deacetylase inhibitor… CONTINUE READING
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