Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development.

@article{Chang2004HistoneD5,
  title={Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development.},
  author={Shurong Chang and Timothy A McKinsey and Chun Li Zhang and James A. Richardson and Joseph A Hill and Eric N Olson},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 19},
  pages={
          8467-76
        }
}
The adult heart responds to stress signals by hypertrophic growth, which is often accompanied by activation of a fetal cardiac gene program and eventual cardiac demise. We showed previously that histone deacetylase 9 (HDAC9) acts as a suppressor of cardiac hypertrophy and that mice lacking HDAC9 are sensitized to cardiac stress signals. Here we report that mice lacking HDAC5 display a similar cardiac phenotype and develop profoundly enlarged hearts in response to pressure overload resulting… CONTINUE READING

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