Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

Abstract

Histone deacetylases (HDACs) are promising pharmacological targets in cancer and autoimmune diseases. All 11 classical HDACs (HDAC1–11) are found in the pancreatic beta cell, and HDAC inhibitors (HDACi) protect beta cells from inflammatory insults. We investigated which HDACs mediate inflammatory beta cell damage and how the islet content of these HDACs is… (More)
DOI: 10.1007/s00125-012-2615-0

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@article{Lundh2012HistoneD1, title={Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children}, author={M. Lundh and D. P. Christensen and M-C. Nielsen and S. J. Richardson and Mattias Salling Dahll{\"o}f and Tine Skovgaard and Jeanette Berthelsen and Charles Anthony Dinarello and Andrea Stevenazzi and Paolo Mascagni and Lars Groth Grunnet and N. G. Morgan and Tom Mandrup-Poulsen}, journal={Diabetologia}, year={2012}, volume={55}, pages={2421-2431} }