Histone deacetylases 1 and 2 regulate autophagy fl ux and skeletal muscle homeostasis in mice

  • Viviana Moresia, M. Carrera, +5 authors Eric N. Olsona
  • Published 2012
Maintenance of skeletal muscle structure and function requires efficient and precise metabolic control. Autophagy plays a key role in metabolic homeostasis of diverse tissues by recycling cellular constituents, particularly under conditions of caloric restriction, thereby normalizing cellular metabolism. Here we show that histone deacetylases (HDACs) 1 and… CONTINUE READING