Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy

@article{Weichert2008HistoneD1,
  title={Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy},
  author={Wilko Weichert and Annika R{\"o}ske and Volker Gekeler and Thomas Beckers and Carsten Stephan and Klaus Jung and Florian Fritzsche and Silvia Niesporek and Carsten Denkert and Manfred Dietel and Glen Kristiansen},
  journal={British Journal of Cancer},
  year={2008},
  volume={98},
  pages={604 - 610}
}
High activity of histone deacetylases (HDACs) causes epigenetic alterations associated with malignant cell behaviour. Consequently, HDAC inhibitors have entered late-phase clinical trials as new antineoplastic drugs. However, little is known about expression and function of specific HDAC isoforms in human tumours including prostate cancer. We investigated the expression of class I HDACs in 192 prostate carcinomas by immunohistochemistry and correlated our findings to clinicopathological… CONTINUE READING
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