Histone deacetylases: Focus on the nervous system

  title={Histone deacetylases: Focus on the nervous system},
  author={Brad E Morrison and Nazanin Majdzadeh and Santosh R. D’Mello},
  journal={Cellular and Molecular Life Sciences},
Neurodegenerative disease strikes millions worldwide and there is mounting evidence suggesting that underlying the onset and progression of these debilitating diseases is inappropriate neuronal apoptosis. Recent reports have implicated a family of proteins known as histone deacetylases (HDACs) in various neuronal processes including the neuronal death program. Initial headway in this field has been made largely through the use of broad-spectrum HDAC inhibitors. In fact, pharmacological… CONTINUE READING