Histone deacetylase inhibitors up-regulate LL-37 expression independent of toll-like receptor mediated signalling in airway epithelial cells

@inproceedings{Liu2012HistoneDI,
  title={Histone deacetylase inhibitors up-regulate LL-37 expression independent of toll-like receptor mediated signalling in airway epithelial cells},
  author={Quan Liu and Juan Liu and Kristina Irene Lisolette Roschmann and Danielle van Egmond and Korneliusz Golebski and Wytske Johanna Fokkens and Dehui Wang and Cornelis Maria van Drunen},
  booktitle={Journal of Inflammation},
  year={2012}
}
HDAC inhibitors have been proposed as anticancer agents. However, their roles in innate genes expression remain not well known. Cathelicidin LL-37 is one of the few human bactericidal peptides, but the regulation of histone acetylation on LL-37 expression in airway epithelium remains largely unknown. Therefore, we investigated the effects of two non-selective HDACi, trichostatin A (TSA) and sodium butyrate (SB), on the expression of the cathelicidin LL-37 in human airway epithelial cells. LL37… CONTINUE READING

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