Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells.

@article{Wu2008HistoneDI,
  title={Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells.},
  author={Yan Wu and Sun-wei Guo},
  journal={European journal of obstetrics, gynecology, and reproductive biology},
  year={2008},
  volume={137 2},
  pages={198-203}
}
  • Yan Wu, Sun-wei Guo
  • Published 2008 in
    European journal of obstetrics, gynecology, and…
OBJECTIVE Following our observation that histone deacetylase inhibitors (HDACIs) trichostatin A (TSA) and valproic acid (VPA) can suppress proliferation of endometrial stromal cells, we sought to determine whether TSA and VPA do so by inducing cell cycle arrest and p21 expression. STUDY DESIGN A recently established immortalized endometrial stromal cell line was treated with TSA, VPA, and/or all-trans retinoic acid (ATRA) and the consequent cell cycle progression was measured by flow… CONTINUE READING

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