Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury.

Abstract

Neuropathic pain is often insensitive to morphine. Our previous study has demonstrated that neuron-restrictive silencer factor represses mu opioid receptor (MOP) gene expression in the dorsal root ganglion (DRG) via histone hypoacetylation-mediated mechanisms after peripheral nerve injury, thereby causing loss of peripheral morphine analgesia. Here, we… (More)
DOI: 10.1016/j.jphs.2015.07.040

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