Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice

@article{Kalda2007HistoneDI,
  title={Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice},
  author={A. Kalda and L. Heidmets and Hai-ying Shen and A. Zharkovsky and Jiang-fan Chen},
  journal={Behavioural Brain Research},
  year={2007},
  volume={181},
  pages={76-84}
}
The behavioral sensitization produced by repeated amphetamine treatment may represent the neural adaptations underlying some of the features of psychosis and addiction in humans. Chromatin modification (specifically histone hyperacetylation) was recently recognized as an important regulator of psychostimulant-induced plasticity. We have investigated the effects of treatment with the histone deacetylase (HDAC) inhibitors butyric acid (BA, 630mg/kg, i.p.) and valproic acid (VPA, 175mg/kg, i.p… Expand
Selective Boosting of Transcriptional and Behavioral Responses to Drugs of Abuse by Histone Deacetylase Inhibition
Sodium butyrate modulates a methamphetamine‐induced conditioned place preference
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