Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse.

  title={Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse.},
  author={Nilamadhab Mishra and Christopher M. Reilly and Doris R Brown and Phil Ruiz and Gary S. Gilkeson},
  journal={The Journal of clinical investigation},
  volume={111 4},
Studies in human systemic lupus erythematosus (SLE) suggest a possible role for histone deacetylases (HDACs) in skewed gene expression and disease pathogenesis. We used the MRL-lpr/lpr murine model of lupus to demonstrate that HDACs play a key role in the heightened levels of both Th1 and Th2 cytokine expression that contribute to disease. The availability of specific HDAC inhibitors (HDIs) such as trichostatin A (TSA) and suberonylanilide hydroxamic acid (SAHA) permits the study of the role of… CONTINUE READING
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Cytokines in the immunopathogenesis of lupus. In Lupus: molecular and cellular pathogenesis

  • B. S. Handwerger, I. Luzina, L. da Silva, C. E. Storrer, C. S. Via
  • 1999
Highly Influential
6 Excerpts

Animal models of systemic lupus erythematosus

  • B. H. Hahn
  • 1997
Highly Influential
6 Excerpts

Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells

  • N Koyama
  • Biochem. Biophys. Res
  • 2002

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