Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines.

@article{GarcaMorales2005HistoneDI,
  title={Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines.},
  author={Pilar Garc{\'i}a-Morales and Angeles G{\'o}mez-Mart{\'i}nez and Alfredo Carrato and Isabel Mart{\'i}nez-Lacaci and V{\'i}ctor Manuel Barber{\'a} and Jos{\'e} Lu{\'i}s Soto and Estefan{\'i}a Carrasco-Garc{\'i}a and Mar{\'i}a P Men{\'e}ndez-Guti{\'e}rrez and Mar{\'i}a D Castro-Galache and Jos{\'e} Antonio Ferragut and Miguel Saceda},
  journal={Molecular cancer therapeutics},
  year={2005},
  volume={4 8},
  pages={1222-30}
}
The antitumor activity of the histone deacetylase inhibitors was tested in three well-characterized pancreatic adenocarcinoma cell lines, IMIM-PC-1, IMIM-PC-2, and RWP-1. These cell lines have been previously characterized in terms of their origin, the status of relevant molecular markers for this kind of tumor, resistance to other antineoplastic drugs, and expression of differentiation markers. In this study, we report that histone deacetylase inhibitors induce apoptosis in pancreatic cancer… CONTINUE READING

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