Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects.

@article{Carlisi2008HistoneDI,
  title={Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects.},
  author={Daniela Carlisi and Barbara Vassallo and Marianna Lauricella and Sonia Emanuele and Antonella D'Anneo and E Di Leonardo and Pietro Di Fazio and Renza Vento and Giovanni Tesoriere},
  journal={International journal of oncology},
  year={2008},
  volume={32 1},
  pages={177-84}
}
This report shows that histone deacetylase inhibitors (HDACIs) induced apoptosis in human hepatoma HepG2 cells in a dose- and time-dependent manner. Trichostatin A (TSA), ITF2357 and suberoylanilide hydroxamic acid (SAHA), which were very effective agents, caused apoptotic effects after a lag phase of 12-16 h. In order to elucidate the mechanism of HDACIs action in HepG2 cells we have studied the effects of TSA, ITF2357 and SAHA on acetylation of p53 and histones H2A, H2B, H3 and H4. It was… CONTINUE READING

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