Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells.

@article{Sonnemann2006HistoneDI,
  title={Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells.},
  author={J{\"u}rgen Sonnemann and K. Saravana Kumar and Sandra Heesch and Cornelia E M{\"u}ller and Christoph Hartwig and Manfred Maass and Peter Bader and James F. Beck},
  journal={International journal of oncology},
  year={2006},
  volume={28 3},
  pages={755-66}
}
Histone deacetylase inhibitors (HDIs) are a promising new class of antineoplastic agents with the ability to induce apoptosis and growth arrest of cancer cells. In addition, HDIs have been suggested to enhance the anticancer efficacy of other therapeutic regimens, such as ionizing radiation (IR) or chemotherapy. The objective of this study was to evaluate the activity of HDIs against medulloblastoma cells when applied either as single agents or in combination with IR, cytostatics, or TRAIL. The… CONTINUE READING
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