Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways.

  title={Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways.},
  author={Jianbin Zhang and Shukie Ng and Jigang Wang and Jing Zhou and Shi-Hao Tan and Naidi Yang and Qingsong Lin and Dajing Xia and Han-ming Shen},
  volume={11 4},
Autophagy is a catabolic process in response to starvation or other stress conditions to sustain cellular homeostasis. At present, histone deacetylase inhibitors (HDACIs) are known to induce autophagy in cells through inhibition of mechanistic target of rapamycin (MTOR) pathway. FOXO1, an important transcription factor regulated by AKT, is also known to play a role in autophagy induction. At present, the role of FOXO1 in the HDACIs-induced autophagy has not been reported. In this study, we… CONTINUE READING
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